Casp2 - caspase 2 Gene

Also Known as ICH-1; Nedd2; CASP-2; NEDD-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12366

About Casp2

Chromosome 6: 42,241,919-42,259,442 forward strand.GRCm39:CM000999.3

This gene has 10 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 16 phenotypes. Ubiquitous expression in thymus adult (RPKM 27.3), limb E14.5 (RPKM 22.2) and 27 other tissues.

Summary

This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced Apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]

Casp2 Products (2)

mRNA Protein Name
NM_007610.3 NP_031636.1 caspase-2 isoform 1 precursor
NM_001409539.1 NP_001396468.1 caspase-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
16183742 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12477715 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12477715 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: Inferred from genetic interaction
11536012 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
11536012 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16183742 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10931486 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12477715 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp2 Protein Structure

CARD_CASP2

CARD_CASP2: cd08332 (31 - 117)

CASc

CASc: smart00115 (191 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

caspase-2

  • neural precursor cell expressed developmentally down-regulated protein 2

  • protease ICH-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P0227 SHU 9119 99.83% Unkown
HY-P1208 PG-931 Agonist 99.60% Unkown
HY-RS01949 CASP2 Human Pre-designed siRNA Set A / Unkown
HY-RS01950 Casp2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01951 Casp2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp2 NCBI NCBI:835