UHMK1 - U2AF homology motif kinase 1 Gene

Also Known as KIS; KIST; P-CIP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 127933

About UHMK1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,497,174-162,529,631 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 18.6), lymph node (RPKM 18.0) and 25 other tissues.

Summary

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

UHMK1 Products (3)

mRNA	Protein	Name
NM_001184763.1	NP_001171692.1	serine/threonine-protein kinase Kist isoform 2
NM_144624.2	NP_653225.2	serine/threonine-protein kinase Kist isoform 3
NM_175866.5	NP_787062.1	serine/threonine-protein kinase Kist isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12093740	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12093740	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12093740	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12093740	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	12093740	GOA
involved in regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	12093740	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	12093740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UHMK1 Protein Structure

Pkinase

RRM_5

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Kist	KIS protein kinase

UHMK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	UHMK1	Q8TAS1	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Flinders Island Spotted Fever	Fisf Thai Tick Typhus
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-RS15444	UHMK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22895	Uhmk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UHMK1	VGNC	VGNC:66809
Canis familiaris	UHMK1	VGNC	VGNC:48122
Macaca mulatta	UHMK1	VGNC	VGNC:79198
Mus musculus	UHMK1	MGD	MGI:1341908
Rattus norvegicus	UHMK1	RGD	RGD:2968
Bos taurus	UHMK1	VGNC	VGNC:36653
Others	UHMK1	NCBI