ELF2 - E74 like ETS transcription factor 2 Gene

Also Known as EU32; NERF; NERF-2; NERF-1A; NERF-1B; NERF-1a,b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1998

About ELF2

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,057,220-139,177,915 (from NCBI)

This gene has 13 transcripts (splice variants), 200 orthologues and 28 paralogues. Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 13.2) and 25 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

ELF2 Products (11)

mRNA	Protein	Name
NM_001276457.2	NP_001263386.1	ETS-related transcription factor Elf-2 isoform 3
NM_001276458.3	NP_001263387.1	ETS-related transcription factor Elf-2 isoform 4
NM_001276459.3	NP_001263388.1	ETS-related transcription factor Elf-2 isoform 5
NM_001331036.3	NP_001317965.1	ETS-related transcription factor Elf-2 isoform 6
NM_001371324.1	NP_001358253.1	ETS-related transcription factor Elf-2 isoform 1
NM_001371336.1	NP_001358265.1	ETS-related transcription factor Elf-2 isoform 7
NM_001371337.1	NP_001358266.1	ETS-related transcription factor Elf-2 isoform 8
NM_001371338.1	NP_001358267.1	ETS-related transcription factor Elf-2 isoform 9
NM_001371339.1	NP_001358268.1	ETS-related transcription factor Elf-2 isoform 10
NM_006874.5	NP_006865.1	ETS-related transcription factor Elf-2 isoform 2
NM_201999.3	NP_973728.1	ETS-related transcription factor Elf-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14970218	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8756667	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14970218	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14970218	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14970218	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8756667	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8756667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELF2 Protein Structure

Elf-1_N

Ets

0
100
200
300
400
500
593 a.a.

Protein Preferred Names	Protein Names
ETS-related transcription factor Elf-2	E74-like factor 2 (ets domain transcription factor)

Related Diseases

Diseases	Alias
Cerebellar Ataxia, Neuropathy, And Vestibular Areflexia Syndrome	CANVAS Cerebellar Ataxia With Neuropathy And Bilateral Vestibular Areflexia Syndrome Cabv Syndrome Cerebellar Ataxia With Bilateral Vestibulopathy Syndrome Ataxia, Cerebellar, Neuropathy, And Vestibular Areflexia Syndrome
Adie Pupil	Adie Syndrome Holmes-Adie Syndrome Poorly Reacting Pupils Adie'S Pupil Or Syndrome Adie'S Pupil Syndrome Adie'S Syndrome Adie'S Pupil Has Tonic, Sluggishly Reacting Pupil And Hypoactive Or Absent Tendon Reflexes Tonic Pupil-Tendon Areflexia Syndrome ADIEP Tonic Pupil
Rectum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Rectum Rectal Squamous Cell Carcinoma Squamous Carcinoma Of Rectum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-153399A	Fosigotifator THAM sodium	Activator	98.03%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-153399	Fosigotifator	Activator	/	Unkown
HY-RS04299	ELF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17275	Efnb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18354	Elf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24833	Elf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ELF2	MGD	MGI:1916507
Felis catus	ELF2	VGNC	VGNC:61806
Macaca mulatta	ELF2	VGNC	VGNC:100222
Canis familiaris	ELF2	VGNC	VGNC:40299
Rattus norvegicus	ELF2	RGD	RGD:1310585
Bos taurus	ELF2	VGNC	VGNC:28427
Others	ELF2	NCBI