ISLR2 - immunoglobulin superfamily containing leucine rich repeat 2 Gene

Also Known as LINX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57611

About ISLR2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,100,318-74,141,826 (from NCBI)

This gene has 11 transcripts (splice variants), 100 orthologues and 3 paralogues. Biased expression in brain (RPKM 4.7), testis (RPKM 3.0) and 5 other tissues.

Summary

Predicted to be involved in positive regulation of axon extension. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

ISLR2 Products (4)

mRNA Protein Name
NM_001130136.1 NP_001123608.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130137.1 NP_001123609.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130138.2 NP_001123610.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_020851.3 NP_065902.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISLR2 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (52 - 109)

LRR_8

LRR_8: Leucine rich repeat (124 - 182)

Ig_2

Ig_2: Immunoglobulin domain (240 - 372)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

immunoglobulin superfamily containing leucine-rich repeat protein 2

  • leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein

ISLR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ISLR2 Q6UXK2 LAPTM4B Homo sapiens Q86VI4
Validated Y2H
32296183
Intra
ISLR2 Q6UXK2 MRAP2 Homo sapiens Q96G30
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Melanotic Medulloblastoma

  • Medulloblastoma, Melanotic
Breast Angiosarcoma

  • Angiosarcoma Of The Breast

  • Hemangiosarcoma Of The Breast

  • Primary Angiosarcoma Of Breast
Breast Sarcoma

  • Sarcoma Of Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06934 ISLR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ISLR2 MGD MGI:2444277
Rattus norvegicus ISLR2 RGD RGD:6497037
Bos taurus ISLR2 VGNC VGNC:30299
Macaca mulatta ISLR2 VGNC VGNC:73682
Canis familiaris ISLR2 VGNC VGNC:59114
Felis catus ISLR2 VGNC VGNC:80947
Others ISLR2 NCBI