RBM4 - RNA binding motif protein 4 Gene

Also Known as LARK; RBM4A; ZCRB3A; ZCCHC21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5936

About RBM4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,638,703-66,668,380 (from NCBI)

This gene has 13 transcripts (splice variants), 72 orthologues and 36 paralogues. Ubiquitous expression in lymph node (RPKM 17.5), ovary (RPKM 17.2) and 25 other tissues.

Summary

Enables RNA binding activity and cyclin binding activity. Involved in several processes, including IRES-dependent translational initiation of linear mRNA; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasmic stress granule; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

RBM4 Products (3)

mRNA	Protein	Name
NM_001198843.2	NP_001185772.1	RNA-binding protein 4 isoform 2
NM_001198844.2	NP_001185773.1	RNA-binding protein 4 isoform 3
NM_002896.4	NP_002887.2	RNA-binding protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	15159402	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21518792	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	19801630	GOA
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	16260624	GOA
enables pre-mRNA intronic pyrimidine-rich binding	IDA IDA: Inferred from direct assay	16260624	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12628928	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in IRES-dependent translational initiation of linear mRNA	IDA IDA: Inferred from direct assay	17284590	GOA
involved in cap-independent translational initiation	IDA IDA: Inferred from direct assay	17284590	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	19801630	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	17284590	GOA
involved in negative regulation of translation in response to stress	IDA IDA: Inferred from direct assay	17284590	GOA
involved in negative regulation of translational initiation	IDA IDA: Inferred from direct assay	19801630	GOA
involved in positive regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	21518792	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	12628928	GOA
involved in regulation of nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	12628928	GOA
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	17284590	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12628928	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	17284590	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	12628928	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12628928	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12628928	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16777844	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM4 Protein Structure

RRM_1

zf-CCHC

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein 4	RNA-binding motif protein 4a

RBM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RBM4	Q9BWF3	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	RBM4	Q9BWF3	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	RBM4	Q9BWF3	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	RBM4	Q9BWF3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RBM4	Q9BWF3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RBM4	Q9BWF3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS11752	RBM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19942	Rbm4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26444	Rbm4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBM4	MGD	MGI:1100865
Rattus norvegicus	RBM4	RGD	RGD:1306891
Others	RBM4	NCBI