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Cat. No.: HY-19242

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MX-68

MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis.

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CAS No.: 156579-02-1
Formule: C₂₂H₂₄N₈O₅S
Masse moléculaire:512.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MX-68 Chemical Structure

CAS No.: 156579-02-1

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

Chemical Information

CAS No. 156579-02-1
Masse moléculaire 512.54
Formule C₂₂H₂₄N₈O₅S
SMILES

O=C(O)[C@@H](NC(C1=CC=C2N(CC3=NC4=C(N)N=C(N)N=C4N=C3)CCSC2=C1)=O)CCCC(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Maruyama N, et al. An improved process for the large-scale preparation of antirheumatic agent MX-68. Organic process research & development, 2004, 8(6): 883-888.

[2]. Mihara M, et al. A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice. Int Arch Allergy Immunol. 1997 Aug;113(4):454-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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