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Cat. No.: HY-117476

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Sapelin B

Sapelin B is a naturally occurring tirucallane-type triterpenoid that exhibits in vivo antitumor activity in a mouse model of P-388 lymphocytic leukemia. Sapelin B can be used in leukemia-related research.

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CAS No.: 26790-94-3
Formule: C₃₀H₅₀O₄
Masse moléculaire:474.72

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sapelin B Chemical Structure

CAS No.: 26790-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
A549	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]

In Vivo

Sapelin B (1.25-10.0 mg/kg) exhibits in vivo antitumor activity in the P-388 lymphocytic leukemia mouse model, with T/C survival ratios ≥ 125% across all tested doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 26790-94-3
Masse moléculaire 474.72
Formule C₃₀H₅₀O₄
SMILES

CC1([C@@H](CC[C@@]2([C@]3(CC[C@]4([C@](CC[C@@]4(C3=CC[C@@]12[H])C)([H])[C@@]5([H])COC(C)(C)[C@@H](O)[C@H](O)C5)C)[H])C)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wu W B, et al. New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata. Journal of Asian Natural Products Research, 2014, 16(7): 709-716.

[2]. Jolad SD, et al. Cytotoxic agents from Bursera klugii (Burseraceae) I: isolation of sapelins A and B. Journal of pharmaceutical sciences. 1977 Jun;66(6):889-90. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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