country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-123958

Copy Link Print Information

SB772077B

SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 785774-34-7

Formule: C₁₅H₁₈N₈O₂

Masse moléculaire:342.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SB772077B Chemical Structure

CAS No.: 785774-34-7

Fast delivery

Free and easy returns

Size

Prix

Stock

Quantité

MOQ

Minimum order quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Obtenir un devis Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Obtenir un devis Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Bulk Inquiry

Other size

Obtenir un devis

Get it by August 31for select sizes. Order within 11 hrs 49 mins.

This product is a controlled substance, please contact local distributor for purchase. This product is a controlled substance and not for sale in your territory.

Amount: USD 0.00

Please select quantity

or

or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

This product is not for sale in your territory.

Data Download

Data Sheet (270 KB)

Instruction de manipulation (2659 KB)

Other Forms of SB772077B:

SB-772077B dihydrochloride
En stock

To place orders, for customer services and technical support, please contact:

609-228-6898

[email protected] [email protected]

Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec

Activité biologique

Chemical Information

Pureté et documentation

Références

Help & FAQs

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Voir tous les produits spécifiques à Isoform ROCK
More

ROCK

ROCK1

ROCK2

Activité biologique

Description

IC₅₀ & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Classifications

Bioz

Activité biologique

Description

SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research^[1]^[2].

IC₅₀ & Target^[1]

Collagen I

Voir tous les produits spécifiques à Isoform ROCK :

ROCK

ROCK1

ROCK2

Cellular Effect

Cell Line

Type Value Description References

Sf9 IC₅₀
5.6 nM
Compound: SB-7720770-B

Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay

Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay
[PMID: 17018693]

Sf9 IC₅₀
5.6 nM
Compound: SB-772077-B

Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method

Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method
[PMID: 31330446]

Chemical Information

CAS No. 785774-34-7

Masse moléculaire 342.36

Formule C₁₅H₁₈N₈O₂

SMILES

NC1=NON=C1C(N2CC)=NC3=C2C(C(N4C[C@@H](N)CC4)=O)=CN=C3

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Ashwinbalaji S, et al. SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes. Sci Rep. 2018 Oct 19;8(1):15472. [Content Brief]

[2]. Dhaliwal J S, et al. Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl) carbonyl)-1-ethyl-1H-imidazo (4, 5-c) pyridin-2-yl)-1, 2, 5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor[J]. The Journal of pharmacology and experimental therapeutics, 2009, 330(1): 334-341.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Concentration Concentration

×
Volume Volume

×
Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

SB772077B Related Classifications

HY-123958 Related Classifications

Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton

ROCK β-catenin Collagen

Aires thérapeutique

Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease Inflammation or Immune System Disease

Visual System Disease Cardiovascular Disease

Glaucoma Hypertension

Neurological Disease Inflammation/Immunology Cardiovascular Disease

Powered by Bioz See more details on Bioz

Keywords

SB772077B
785774-34-7
ROCK
β-catenin
Collagen
HTM cells
aqueous outflow facility
RhoA/ROCK
anti-inflammatory
vasodialatory
glaucoma
pulmonary hypertensive disorder
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

SB772077B

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

Subscribe

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	5.6 nM Compound: SB-7720770-B	Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay	[PMID: 17018693]
Sf9	IC₅₀	5.6 nM Compound: SB-772077-B	Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as substrate incubated for 90 mins in presence of [gamma33P]ATP by scintillation counting method	[PMID: 31330446]

100 mg

Obtenir un devis En stock

Please select quantity

Amount: USD 0.00

Activité biologique

Description

IC₅₀ & Target

Chemical Information

Pureté et documentation

Références

Sign in to MedChemExpress Sign In

Enregistrer

Sign in to MedChemExpress

Keep me logged in. Mot de passe oublié

Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes

Check out faster

Add multiple shipping locations

View orders

Assay Types

1/16

Demande en ligne

Your information is safe with us. *Required Fields.

Nom du produit *
Field is required.

Requested Quantity *
Field is required.

Nom du demandeur *
Field is required.

Civilité *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Numéro de téléphone *
Field is required.

Department

Nom de l''organisation *
Field is required.

Ville

Etat Etat *
Field is required.

Pays ou Région *
Field is required.

Container *
Field is required.

MCE Japan Authorized Agent:

ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社

Remarques

Request for Report

Please fill out this form to request the report. We will send it to your Email address shortly.
Your information is safe with us. *Required Fields.

Nom du produit *
Field is required.

Lot # *
Field is required.

Nom du demandeur *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Numéro de téléphone
Field is required.

Department *
Field is required.

Nom de l''organisation *
Field is required.

Pays ou Région *
Field is required.

Remarques

Bulk Inquiry Request for Report Demande en ligne Avis client Request for Recombinant Proteins Catalog

We have received your request and will respond to you as soon as possible. Congratulations! Uh-oh!

We have received your inquiry regarding and will respond to you as soon as possible. We have received your request and will respond to you as soon as possible. Thank You for Your Feedback! This product is a controlled substance and not for sale in your territory. It appears that we were unable to send an email to . Please verify your email address and try again!

Inquiry Information

Nom du produit:

Cat. No.:

Quantité:

MCE Japan Authorized Agent:

Inquiry Information

Nom du produit:

CAS No.:

Species:

Pureté:

Quantité:

Licensing Opportunities

Your information is safe with us. *Required Fields.

Nom du demandeur *
Field is required.

Civilité *
Field is required.

Role/Position *
Field is required.

Nom de l''organisation *
Field is required.

Pays ou Région *
Field is required.

Etat Etat *
Field is required.

Email *
Field is required.

Please enter a valid Email Address.

Numéro de téléphone *
Field is required.

Nom du produit
Field is required.

CAS No.
Field is required.

Remarques

MedChemExpress

MedChemExpress

Contactez-nous

Qui sommes-nous

Siège social

Distributeurs

Déclaration sur le faux rapport

Carrières

Support pour client

Support pour client

Support technique

Service

Informations pour commander

Retour facile

Tarifs et conditions de livraison

Termes et conditions

Potentiel de propriété intellectuelle

Ressources

Ressources

Échantillons gratuits

Revues scientifiques

Topics

Product Guides

Blogs

Protocols

Brochures

Promotions

Events and Webinars

Gènes

Biomedical Dictionary

Subscribe to our E-newsletter

Sorry, but the email address you supplied was invalid.

Thanks, your subscription has been confirmed. You will hear from us soon.

Submission failed, please try again later.

Les produits sont des réactifs chimiques destinés uniquement à la recherche et ne sont pas destinés à un usage humain. Nous ne vendons pas aux patients.

Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

Carte du Site | Politique de Confidentialité

Online Service Online Customer Service

Contact Us

Happy to help!

MedChemExpress

Tel: 609-228-6898

E-mail: [email protected]

Technical Support: [email protected]

MedChemExpress

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent: