1015856-57-1
1015856-57-1
Chemical Structure
Norfloxacin-d5
- CAS No.: 1015856-57-1
- Formula:C16H13D5FN3O3
- Molecular Weight:324.36
IUPAC Name: 1-(ethyl-d5)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: OGJPXUAPXNRGGI-ZBJDZAJPSA-N
SMILES: O=C(C1=CN(C([2H])([2H])C([2H])([2H])[2H])C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O
Biological Activity: Norfloxacin-d5 is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase[1][2].
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Norfloxacin-d5 | 99.91% | Norfloxacin-d5 is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. | ||||||||||||||||||||
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Norfloxacin (Standard) | 99.81% | Norfloxacin (Standard) is the analytical standard of Norfloxacin. This product is intended for research and analytical applications. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. | ||||||||||||||||||||
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Norfloxacin-d8 | Norfloxacin-d8 is the deuterium labeled Norfloxacin. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. | |||||||||||||||||||||
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Norfloxacin | 98.31% | Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. | ||||||||||||||||||||
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References
- [1]. Russak EM, et, al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Pohlhaus JR, et, al. Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. Mol Microbiol. 2005 Jun;56(6):1416-29. [Content Brief]
