1254771-90-8
Chemical Structure
4-Fluorobenzeneboronic acid-d4
Synonym(s): P-Fluorophenylboronic acid-d4
- CAS No.: 1254771-90-8
- Formula:C6H2D4BFO2
- Molecular Weight:143.94
IUPAC Name: (4-fluorophenyl-2,3,5,6-d4)boronic acid
InChIKey: LBUNNMJLXWQQBY-RHQRLBAQSA-N
SMILES: [2H]C1=C(B(O)O)C([2H])=C([2H])C(F)=C1[2H]
Biological Activity: 4-Fluorobenzeneboronic acid-d4 (P-Fluorophenylboronic acid-d4) is the deuterated-labeled 4-Fluorobenzeneboronic acid (HY-I0201). 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps[1][2].
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4-Fluorobenzeneboronic acid-d4 | 4-Fluorobenzeneboronic acid-d4 (P-Fluorophenylboronic acid-d4) is the deuterated-labeled 4-Fluorobenzeneboronic acid (HY-I0201). 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps. | |||||||||||||||||||||
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4-Fluorobenzeneboronic acid | 98.0% | 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps. | ||||||||||||||||||||
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References
- [1]. Erami R S, et al. Suzuki-Miyaura CC coupling reactions catalyzed by supported Pd nanoparticles for the preparation of fluorinated biphenyl derivatives[J]. Catalysts, 2017, 7(3): 76.
- [2]. Wang X, et al. Copper-catalyzed synthesis of sulfonamides from nitroarenes via the insertion of sulfur dioxide. Chemical communications (Cambridge, England). 2020 Mar 19;56(23):3437-3440.
