136583-72-7
136583-72-7
Chemical Structure
CGS 24565
- CAS No.: 136583-72-7
- Formula:C57H77N3O12
- Molecular Weight:996.23
InChIKey: CGBMSJVNJLFYAU-RJDDPJNKSA-N
SMILES: C[C@H]([C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@](O1)(C)[C@H](O)C2=C1C(C)=C(OC(C(C)(C)C)=O)C3=C4C(N=C5O4)=C(N6CCN(CC7=C(C=C(C=C7C)C)C)CC6)C(OC)=C32)/C=C/C=C5/C
Biological Activity: CGS 24565, a derivative of the antibiotic Rifamycin (HY-B1907A), is an orally active hypolipidemic agent. CGS 24565 can reduce plasma cholesterol levels in both primate and nonprimate species[1][2].
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CGS 24565 | CGS 24565, a derivative of the antibiotic Rifamycin (HY-B1907A), is an orally active hypolipidemic agent. CGS 24565 can reduce plasma cholesterol levels in both primate and nonprimate species. | |||||||||||||||||||||
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References
- [1]. Gibson JC, et al. The ansamycins: hypolipidemic agents stimulating cholesterol removal by nonclassical mechanisms. J Lipid Res. 1994 Sep;35(9):1524-34. [Content Brief]
- [2]. Schiavo DM, et al. Ocular changes in beagle dogs following oral administration of CGS 24565, a potential hypolipidemic agent. Toxicol Sci. 2000 May;55(1):189-94. [Content Brief]
Keywords
