1439268-65-1
Chemical Structure
LA1011
- CAS No.: 1439268-65-1
- Formula:C25H36Cl2F3N3O4
- Molecular Weight:570.47
IUPAC Name: dimethyl 2,6-bis(2-(dimethylamino)ethyl)-1-methyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
InChIKey: XWQSXVBFMUCWSR-UHFFFAOYSA-N
SMILES: O=C(C1=C(CCN(C)C)N(C)C(CCN(C)C)=C(C1C2=CC=C(C(F)(F)F)C=C2)C(OC)=O)OC.Cl.Cl
Biological Activity: LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease[1].
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LA1011 | LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease. | |||||||||||||||||||||
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