159776-69-9
Chemical Structure
Cemadotin
Synonym(s): LU103793 free base
- CAS No.: 159776-69-9
- Formula:C35H56N6O5
- Molecular Weight:640.86
IUPAC Name: (S)-N-benzyl-1-((S)-1-((S)-2-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide
InChIKey: XSAKVDNHFRWJKS-IIZANFQQSA-N
SMILES: CC(C)[C@H](N(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC3=CC=CC=C3)=O)=O)=O)=O)=O
Biological Activity: Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1][2].
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Cemadotin | Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer. | |||||||||||||||||||||
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References
- [1]. Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8. [Content Brief]
- [2]. Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4. [Content Brief]
