18133-22-7
Chemical Structure
Netropsin dihydrochloride
- CAS No.: 18133-22-7
- Formula:C18H28Cl2N10O3
- Molecular Weight:503.39
IUPAC Name: N-(3-amino-3-iminopropyl)-4-(4-(2-guanidinoacetamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamide dihydrochloride
InChIKey: SDRHUASONSRLFR-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2.[H]Cl.[H]Cl
Biological Activity: Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][4][5].
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Netropsin dihydrochloride | 98.54% | Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity. | ||||||||||||||||||||
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- [1]. Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. [Content Brief]
- [4]. Smee DF, et, al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]
- [5]. Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73(1): 341-343.
Keywords
