1868065-21-7
Chemical Structure
Vicadrostat
Synonym(s): BI 690517
- CAS No.: 1868065-21-7
- Formula:C15H12ClN3O3
- Molecular Weight:317.73
InChIKey: MCVIVPZYYMNCAW-OAHLLOKOSA-N
SMILES: O=C1C2=C(C[C@@](C)(O1)CO)N=CN2C3=CC(Cl)=C(C=C3)C#N
Biological Activity: Vicadrostat (BI 690517) is an orally active aldosterone synthase (aldosterone synthase) inhibitor, with IC50 values of 19 nM, 16 nM, and 18 μM against human, cynomolgus monkey, and rat aldosterone synthase, respectively. Vicadrostat has an in vivo IC50 of 25 nM for aldosterone synthesis. Vicadrostat exhibits high selectivity for cortisol synthase; it reduces aldosterone production and decreases plasma aldosterone levels. Vicadrostat can be used in the research of chronic kidney disease, heart failure, and hypertension[1].
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Vicadrostat | 98.67% | Vicadrostat (BI 690517) is an orally active aldosterone synthase (aldosterone synthase) inhibitor, with IC50 values of 19 nM, 16 nM, and 18 μM against human, cynomolgus monkey, and rat aldosterone synthase, respectively. Vicadrostat has an in vivo IC50 of 25 nM for aldosterone synthesis. Vicadrostat exhibits high selectivity for cortisol synthase; it reduces aldosterone production and decreases plasma aldosterone levels. Vicadrostat can be used in the research of chronic kidney disease, heart failure, and hypertension. | ||||||||||||||||||||
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Keywords
