2183338-59-0
2183338-59-0
Chemical Structure
H3R antagonist 6
- CAS. Nr.: 2183338-59-0
- Formula:C19H25FN2O
- Molecular Weight:316.41
SMILES: O=C(N1CCN(C2CCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3
Biological Activity: H3R antagonist 6 (Compounds 3) (H3-2406) is a Histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. H3R antagonist 6 labeled with 18F has high radiochemical yield, molar activity and moderate brain uptake, but with an off-target binding to the Sigma-1 receptor. H3R antagonist 6 can be used as a PET radioligand for positron emission tomography imaging for central nervous system (CNS) disorders research[1].
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H3R antagonist 6 | H3R antagonist 6 (Compounds 3) (H3-2406) is a Histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. H3R antagonist 6 labeled with 18F has high radiochemical yield, molar activity and moderate brain uptake, but with an off-target binding to the Sigma-1 receptor. H3R antagonist 6 can be used as a PET radioligand for positron emission tomography imaging for central nervous system (CNS) disorders research. | |||||||||||||||||||||
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References
Keywords
