H3R antagonist 6
H3R antagonist 6 (Compounds 3) (H3-2406) is a Histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. H3R antagonist 6 labeled with 18F has high radiochemical yield, molar activity and moderate brain uptake, but with an off-target binding to the Sigma-1 receptor. H3R antagonist 6 can be used as a PET radioligand for positron emission tomography imaging for central nervous system (CNS) disorders research.
For research use only. We do not sell to patients.
- CAS No.: 2183338-59-0
- Formula: C19H25FN2O
- Molecular Weight:316.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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H3 receptor 5.6 nM (IC50) |
Sigma 1 Receptor |
Chemical Information
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CAS No. 2183338-59-0
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Molecular Weight 316.41
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Formula C19H25FN2O
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SMILES
O=C(N1CCN(C2CCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H3R antagonist 6 Related Classifications
HY-175367 Related Classifications
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