2478-35-5
Chemical Structure
Cellohexaose
- CAS No.: 2478-35-5
- Formula:C36H62O31
- Molecular Weight:990.86
IUPAC Name: (2R,3R,4R,5R)-4-(((2S,3R,4R,5S,6R)-5-(((2S,3R,4R,5S,6R)-5-(((2S,3R,4R,5S,6R)-5-(((2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,6-tetrahydroxyhexanal
InChIKey: DJMVHSOAUQHPSN-VXDFXQCISA-N
SMILES: O[C@H]1[C@]([C@H](O[C@@H](O[C@]([C@@H]2O)([H])[C@H](O[C@@H](O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)[C@@H]2O)CO)[C@@H]1O)CO)([H])O[C@@H]([C@@H]([C@@H](O)[C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)O)([H])O[C@@H]4CO)O)O[C@@H]3CO
Biological Activity: Cellohexaose is a YKL-40 carbohydrate-binding ligand that occupies the primary carbohydrate-binding cleft through carbohydrate-π stacking and hydrogen-bonding interactions, and can serve as a bioinert spacer for hybrid glyco-nanolayers, modulating the surface density of bioactive shell hexaose to enhance TLR2-mediated responses. Cellohexaose is used in research on chronic inflammatory diseases and cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cellohexaose | 99.95% | Cellohexaose is a YKL-40 carbohydrate-binding ligand that occupies the primary carbohydrate-binding cleft through carbohydrate-π stacking and hydrogen-bonding interactions, and can serve as a bioinert spacer for hybrid glyco-nanolayers, modulating the surface density of bioactive shell hexaose to enhance TLR2-mediated responses. Cellohexaose is used in research on chronic inflammatory diseases and cancer. | ||||||||||||||||||||
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References
- [1]. Kognole A, et al. Inhibition of Mammalian Glycoprotein YKL-40. Journal of Biological Chemistry, 2017; 292, 2624-2636.
- [2]. Yoshiike Y. Tailoring hybrid glyco-nanolayers composed of chitohexaose and cellohexaose for cell culture applications. Journal of Materials Chemistry. 2011 Jul 19;21(30):11150-8.
- [3]. Takuya Kitaoka, et al. Synthesis and bio-applications of carbohydrate-gold nanoconjugates with nanoparticle and nanolayer forms, Materials Science and Engineering: C, Volume 31, Issue 6, 2011, Pages 1221-1229, ISSN 0928-4931.
- [4]. Bolam DN, et al. Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity. The Biochemical journal. 1998 May 01;331 ( Pt 3)(Pt 3):775-81.
- [5]. Hatakeyama M, et al. Direct stimulation of cellular immune response via TLR2 signaling triggered by contact with hybrid glyco-biointerfaces composed of chitohexaose and cellohexaose. Colloids and surfaces. B, Biointerfaces. 2019 Mar 01;175:517-522.
- [6]. Yuka Yoshiike, et al. Tailoring hybrid glyco-nanolayers composed of chitohexaose and cellohexaose for cell culture applications. J. Mater. Chem. 2011; 21 (30): 11150-11158.
