262442-90-0
262442-90-0
Chemical Structure
BSF-466895
Synonym(s): A-422885.66
- CAS No.: 262442-90-0
- Formula:C29H32Cl2FN7O2S
- Molecular Weight:632.58
IUPAC Name: N-(4-(4-amino-7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-2,3-dichlorobenzenesulfonamide
InChIKey: LCMWDFXRHRLQPG-MXVIHJGJSA-N
SMILES: O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C6=NC=NC(N)=C63)C=C2F)=O
Biological Activity: BSF-466895(A-422885.66) is a Tie2 inhibitor with an IC50 of 5 nM and it can also inhibit Tie1[1][2].
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BSF-466895 | BSF-466895(A-422885.66) is a Tie2 inhibitor with an IC50 of 5 nM and it can also inhibit Tie1. | |||||||||||||||||||||
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References
- [1]. Jerry Adams, et al. A strategy for the design of multiplex inhibitors for kinase-mediated signalling in angiogenesis. Curr Opin Chem Biol. 2002 Aug;6(4):486-92. [Content Brief]
- [2]. Dieter Marmé, et al. The impact of anti-angiogenic agents on cancer therapy. J Cancer Res Clin Oncol. 2003 Nov;129(11):607-20. [Content Brief]
