264262-71-7
264262-71-7
Chemical Structure
SB-414796
- CAS 番号: 264262-71-7
- Formula:C29H36N4O4S
- Molecular Weight:536.69
IUPAC Name: 3-(5-methyl-1,2,4-oxadiazol-3-yl)-N-((1r,4r)-4-(2-(7-(methylsulfonyl)-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexyl)benzamide
InChIKey: ZHQUFEJLPBTKSM-WVPZODRTSA-N
SMILES: CS(C1=CC2=C(C=C1)CCN(CC2)CC[C@H]3CC[C@@H](CC3)NC(C4=CC=CC(C5=NOC(C)=N5)=C4)=O)(=O)=O
Biological Activity: SB-414796 is a selective, orally active and cross the blood-brain barrier dopamine D3 receptor antagonist with Ki values of 4, 400 nM for D3, D2, respectively[1][2].
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SB-414796 | SB-414796 is a selective, orally active and cross the blood-brain barrier dopamine D3 receptor antagonist with Ki values of 4, 400 nM for D3, D2, respectively. | |||||||||||||||||||||
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References
- [1]. Macdonald GJ, et al. Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. J Med Chem. 2003 Nov 6;46(23):4952-64. [Content Brief]
- [2]. Heidbreder CA, et al. Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Ann N Y Acad Sci. 2010 Feb;1187:4-34. [Content Brief]
