26844-12-2
Chemical Structure
Indoramin
Synonym(s): Indoramine; Wy 21901
- CAS No.: 26844-12-2
- Formula:C22H25N3O
- Molecular Weight:347.45
IUPAC Name: N-(1-(2-(1H-indol-3-yl)ethyl)piperidin-4-yl)benzamide
InChIKey: JXZZEXZZKAWDSP-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CCC2=CNC3=C2C=CC=C3)CC1)C4=CC=CC=C4
Biological Activity: Indoramin (Wy 21901) is a competitive and selective α1-adrenoceptor antagonist. Indoramin reduces peripheral vascular resistance, blood pressure, heart rate and myocardial contractility in experimental animals. Under hypoxic conditions, Indoramin increases ATP synthesis in brain tissue, maintains cerebral ATP levels, and alleviates hypoxia-related swelling of synaptosomes, cerebral microvessels and the whole brain. Indoramin can be used in studies related to hypertension, cardiovascular regulation and cerebral hypoxia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Indoramin | 99.03% | Indoramin (Wy 21901) is a competitive and selective α1-adrenoceptor antagonist. Indoramin reduces peripheral vascular resistance, blood pressure, heart rate and myocardial contractility in experimental animals. Under hypoxic conditions, Indoramin increases ATP synthesis in brain tissue, maintains cerebral ATP levels, and alleviates hypoxia-related swelling of synaptosomes, cerebral microvessels and the whole brain. Indoramin can be used in studies related to hypertension, cardiovascular regulation and cerebral hypoxia. | ||||||||||||||||||||
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Indoramin (Standard) | ≥98% | Indoramin (Standard) is the analytical standard of Indoramin. This product is intended for research and analytical applications. Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor. | ||||||||||||||||||||
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Indoramin-d5 | Indoramin-d5 is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent. | |||||||||||||||||||||
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References
- [1]. Alps BJ, et al. A comparison of the cardiovascular actions of indoramin, propranolol, lignocaine, and quinidine. Cardiovasc Res. 1972;6:226-234.
- [2]. Wyllie MG, et al. Adenosinetriphosphate conservation by indoramin and other drugs. Biochem Pharmacol. 1981;30(12):1605-1612.
- [3]. Algate DR, et al. Cardioregulatory properties of indoramin in the rat. The Journal of pharmacy and pharmacology. 1981 Apr;33(4):236-9.
- [4]. Eltze M, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. European journal of pharmacology. 1996 Jan 04;295(1):69-73. [Content Brief]
