2766179-68-2
2766179-68-2
Chemical Structure
PROTAC BRD4 Degrader-46
- CAS No.: 2766179-68-2
- Formula:C35H34ClN9O4S
- Molecular Weight:712.22
InChIKey: DVEXWCXHNDXYPA-MHZLTWQESA-N
SMILES: O=C(N1)CCN(C2=CC=C(C(CC(NCCNC(C[C@@H](C3=NN=C(N43)C)N=C(C5=C4SC(C)=C5C)C6=CC=C(C=C6)Cl)=O)=O)=CN7)C7=C2)C1=O
Biological Activity: PROTAC BRD4 Degrader-46 is a heterobifunctional BRD4 PROTAC degrader. PROTAC BRD4 Degrader-46 binds to both BRD4 and CRBN, thereby triggering ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-46 downregulates the levels of downstream BRD2, BRD3 and MYC. PROTAC BRD4 Degrader-46 can be used in the research of cancers such as multiple myeloma[1].
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PROTAC BRD4 Degrader-46 | PROTAC BRD4 Degrader-46 is a heterobifunctional BRD4 PROTAC degrader. PROTAC BRD4 Degrader-46 binds to both BRD4 and CRBN, thereby triggering ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-46 downregulates the levels of downstream BRD2, BRD3 and MYC. PROTAC BRD4 Degrader-46 can be used in the research of cancers such as multiple myeloma. | |||||||||||||||||||||
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