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Art. -Nr.: HY-182801

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PROTAC BRD4 Degrader-46

PROTAC BRD4 Degrader-46 is a heterobifunctional BRD4 PROTAC degrader. PROTAC BRD4 Degrader-46 binds to both BRD4 and CRBN, thereby triggering ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-46 downregulates the levels of downstream BRD2, BRD3 and MYC. PROTAC BRD4 Degrader-46 can be used in the research of cancers such as multiple myeloma.
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon E3 ligase ligand; Black: linker).

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CAS. Nr.: 2766179-68-2
Formel: C₃₅H₃₄ClN₉O₄S
Molecular Weight:712.22

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BRD4 Degrader-46 Chemical Structure

CAS. Nr.: 2766179-68-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Biologische Aktivität

Beschreibung

PROTAC BRD4 Degrader-46 is a heterobifunctional BRD4 PROTAC degrader. PROTAC BRD4 Degrader-46 binds to both BRD4 and CRBN, thereby triggering ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-46 downregulates the levels of downstream BRD2, BRD3 and MYC. PROTAC BRD4 Degrader-46 can be used in the research of cancers such as multiple myeloma^[1]. (Pink: BRD4 ligand (HY-78695); Blue: Cereblon E3 ligase ligand; Black: linker).

IC₅₀ & Target^[1]

Cereblon

BRD4

BRD2

BRD3

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC BRD4 Degrader-46 (Compound 6) (5 h) potently degrades BRD4 via a CRBN-dependent mechanism in HiBiT-BRD4-tagged HEK293 cells, with a DC₅₀ of 172 nM and a D_max of up to 95%^[1].
PROTAC BRD4 Degrader-46 (0.003-1 μM; 5 h) selectively degrades BRD4, BRD2, BRD3 and MYC in NB-4 cells, without degrading IMiD-related neo-substrates Ikaros, Aiolos, GSPT1, CSNK1A1 and RAB28^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2766179-68-2
Molecular Weight 712.22
Formel C₃₅H₃₄ClN₉O₄S
SMILES

O=C(N1)CCN(C2=CC=C(C(CC(NCCNC(C[C@@H](C3=NN=C(N43)C)N=C(C5=C4SC(C)=C5C)C6=CC=C(C=C6)Cl)=O)=O)=CN7)C7=C2)C1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Rodrigo-Brenni MC, et al. A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader. Nat Commun. Published online March 25, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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PROTAC BRD4 Degrader-46

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PROTAC BRD4 Degrader-46 Related Classifications

HY-182801 Related Classifications