3025180-14-4
Chemical Structure
Microtubulin-IN-1
- CAS No.: 3025180-14-4
- Formula:C25H21FN4O3
- Molecular Weight:444.46
InChIKey: FOOJQHCVDSCOOB-NMGXZBPKSA-N
SMILES: FC1=CC=C(C(C2=CC=CC(/C=C3NC(/C(NC\3=O)=C/C4=NC=CN4C(C)C)=O)=C2)=O)C=C1
Biological Activity: Microtubulin-IN-1 (Compound 8g) is the inhibitor for microtubulin that targets colchicine-binding site, disrupts the microtubulin integrity, and induces the upregulation of p53. Microtubulin-IN-1 exhibits antiproliferative activity in a variety of cancer cell lines (IC50 for NCI-H460, BxPC-3 and HT-29 is 2.4, 1.6 and 2.07 nM, respectively), arrests the cell cycle at G2/M phase, and induces apoptosis in NCI-H460[1].
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Microtubulin-IN-1 | Microtubulin-IN-1 (Compound 8g) is the inhibitor for microtubulin that targets colchicine-binding site, disrupts the microtubulin integrity, and induces the upregulation of p53. Microtubulin-IN-1 exhibits antiproliferative activity in a variety of cancer cell lines (IC50 for NCI-H460, BxPC-3 and HT-29 is 2.4, 1.6 and 2.07 nM, respectively), arrests the cell cycle at G2/M phase, and induces apoptosis in NCI-H460. | |||||||||||||||||||||
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Keywords
