3030492-59-9
Chemical Structure
Ebselen derivative 1
- CAS No.: 3030492-59-9
- Formula:C13H10N2O2Se
- Molecular Weight:305.19
InChIKey: GEHIPFLROXEEOQ-UHFFFAOYSA-N
SMILES: O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2
Biological Activity: Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1].
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Ebselen derivative 1 | Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss . | |||||||||||||||||||||
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Keywords
