3041997-77-4
Chemical Structure
NF-κB-IN-22
- CAS No.: 3041997-77-4
- Formula:C34H43ClN2O14Pt
- Molecular Weight:934.25
InChIKey: YEGXKHJSNZZOBX-MODYJWQLSA-J
SMILES: COC(C=CC(/C=C/C(C1=CC(OC)=C(C(OC)=C1)OC)=O)=C2)=C2OCCOC(CCCC([O-][Pt+4]34([NH2][C@]5([H])[C@@](CCCC5)([H])[NH2]3)([O-]C(C([O-]4)=O)=O)[Cl-])=O)=O
Biological Activity: NF-κB-IN-22 is an inhibitor targeting IKKβ, IκBα and NF-κB p65. NF-κB-IN-22 selectively inhibits the proliferation, migration and invasion of various cancer cells, arrests the cell cycle, and suppresses tumor growth in vivo, while exhibiting low toxicity to normal cells. NF-κB-IN-22 induces DNA damage, ROS production and apoptosis through endoplasmic reticulum stress and mitochondrial apoptotic pathways. NF-κB-IN-22 inhibits the phosphorylation of IKKβ, IκBα and NF-κB p65, blocks the NF-κB signaling pathway, and suppresses the nuclear translocation of NF-κB p65. NF-κB-IN-22 reverses the resistance to cisplatin (HY-17394). NF-κB-IN-22 can be used in research related to lung cancer, gastric cancer and liver cancer[1].
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NF-κB-IN-22 | NF-κB-IN-22 is an inhibitor targeting IKKβ, IκBα and NF-κB p65. NF-κB-IN-22 selectively inhibits the proliferation, migration and invasion of various cancer cells, arrests the cell cycle, and suppresses tumor growth in vivo, while exhibiting low toxicity to normal cells. NF-κB-IN-22 induces DNA damage, ROS production and apoptosis through endoplasmic reticulum stress and mitochondrial apoptotic pathways. NF-κB-IN-22 inhibits the phosphorylation of IKKβ, IκBα and NF-κB p65, blocks the NF-κB signaling pathway, and suppresses the nuclear translocation of NF-κB p65. NF-κB-IN-22 reverses the resistance to cisplatin (HY-17394). NF-κB-IN-22 can be used in research related to lung cancer, gastric cancer and liver cancer. | |||||||||||||||||||||
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