3047446-75-0
3047446-75-0
Chemical Structure
FGFR-IN-14
- CAS No.: 3047446-75-0
- Formula:C24H19F2N7O2
- Molecular Weight:475.45
InChIKey: GKKSEORWFYILJW-UHFFFAOYSA-N
SMILES: CC(N1)=NC2=C1C=C(F)C(C#CC3=NN(CC4=CC=CC(NC(C=C)=O)=C4)C(N)=C3C(N)=O)=C2F
Biological Activity: FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC50s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC50s of 19, 59, and 73 nM, respectively[1].
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FGFR-IN-14 | FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC50s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC50s of 19, 59, and 73 nM, respectively. | |||||||||||||||||||||
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References
Keywords
