322728-21-2
322728-21-2
Chemical Structure
2-Thio-2'-deoxycytidine-5'-triphosphate
Synonym(s): 2-Thio-dCTP
- CAS No.: 322728-21-2
- Formula:C9H16N3O12P3S
- Molecular Weight:483.22
InChIKey: VCHURPMMWRACNQ-SHYZEUOFSA-N
SMILES: NC(C=CN1[C@H]2C[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=S
Biological Activity: 2-Thio-2'-deoxycytidine-5'-triphosphate (2-Thio-dCTP) is a dCTP (HY-101400A) analog that serves as a substrate for Sulfolobus solfataricus DNA polymerase Dpo4. 2-Thio-2'-deoxycytidine-5'-triphosphate incorporates opposite G and O6-MeG templates, exhibiting improved selectivity for O6-MeG relative to dCTP without significant loss of incorporation efficiency[1][2].
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2-Thio-2'-deoxycytidine-5'-triphosphate | 2-Thio-2'-deoxycytidine-5'-triphosphate (2-Thio-dCTP) is a dCTP (HY-101400A) analog that serves as a substrate for Sulfolobus solfataricus DNA polymerase Dpo4. 2-Thio-2'-deoxycytidine-5'-triphosphate incorporates opposite G and O6-MeG templates, exhibiting improved selectivity for O6-MeG relative to dCTP without significant loss of incorporation efficiency. | |||||||||||||||||||||
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References
- [1]. Stornetta A, et al. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Chembiochem : a European journal of chemical biology. 2013 Sep 02;14(13):1634-9.
- [2]. Gül OT, et al. Single Molecule Bioelectronics and Their Application to Amplification-Free Measurement of DNA Lengths. Biosensors. 2016 Jun 24;6(3):29. [Content Brief]
