Deoxycytidine triphosphate trisodium solution (100 mM)  (Synonyms: dCTP trisodium solution (100 mM); 2′-Deoxycytidine-5′-triphosphate trisodium solution (100 mM))

Deoxycytidine triphosphate trisodium (dCTP trisodium) solution (100 mM) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing^[1][2][3].

Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C^[1].
Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

533.10

C₉H₁₃N₃Na₃O₁₃P₃

109909-44-6

Liquid

Colorless to light yellow

O[C@H]([C@H](O1)COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N2C=CC(N)=NC2=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. A W Harris, et al. Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1979 Feb;39(2 Pt 1):538-41.  [Content Brief]

  [2]. B A Bladergroen, et al. CTP:phosphoethanolamine cytidylyltransferase. Biochim Biophys Acta. 1997 Sep 4;1348(1-2):91-9.  [Content Brief]

  [3]. M H Tattersall, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975 Apr;5(2):191-202.  [Content Brief]