524924-76-3
524924-76-3
Chemical Structure
Methoxy-PEPy
- CAS No.: 524924-76-3
- Formula:C13H10N2O
- Molecular Weight:210.23
IUPAC Name: 3-methoxy-5-(pyridin-2-ylethynyl)pyridine
InChIKey: VRTFKUFTEWQHDD-UHFFFAOYSA-N
SMILES: COC1=CC(C#CC2=NC=CC=C2)=CN=C1
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methoxy-PEPy | 98.69% | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. | ||||||||||||||||||||
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References
- Cosford ND, et al. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. [Content Brief]
- Anderson JJ, et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol. 2003 Jul 18;473(1):35-40. [Content Brief]
- Salisbury BG, et al. Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. Eur J Pharmacol. 2008 Jan 28;579(1-3):34-9. [Content Brief]
