[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

  • Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. doi: 10.1016/s0960-894x(02)00997-6.
Nicholas D P Cosford  1 ,  Jeffrey Roppe ,  Lida Tehrani ,  Edwin J Schweiger ,  T Jon Seiders ,  Ashok Chaudary ,  Sara Rao ,  Mark A Varney
Affiliations
  • 1. Department of Chemistry, Merck Research Laboratories, MRLSDB2, 3535, General Atomics Court, San Diego, CA 92121, USA. [email protected]
PMID: 12565928 DOI: 10.1016/s0960-894x(02)00997-6
Abstract

The design, synthesis, and characterization of two potent, non-competitive radioligands, [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy, that are selective for the mGlu5 receptor are described.

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