60-87-7
60-87-7
Chemical Structure
Promethazine
Synonym(s): (±)-Promethazine
- CAS No.: 60-87-7
- Formula:C17H20N2S
- Molecular Weight:284.42
IUPAC Name: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
InChIKey: PWWVAXIEGOYWEE-UHFFFAOYSA-N
SMILES: CC(N(C)C)CN1C2=C(C=CC=C2)SC3=CC=CC=C31
Biological Activity: Promethazine is an orally active histamine receptor antagonist[1]. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects[1][2][3][4].
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Promethazine | 99.67% | Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects. | ||||||||||||||||||||
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Promethazine (Standard) | ≥98% | Promethazine (Standard) is the analytical standard of Promethazine. This product is intended for research and analytical applications. Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects. | ||||||||||||||||||||
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Promethazine-d4 | Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties. | |||||||||||||||||||||
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Ethopropazine hydrochloride | 99.32% | Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease. | ||||||||||||||||||||
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Fenethazine | Fenethazine (Phenethazine) is a compound with antihistamine activity. It is an effective antihistamine. Its congeners also have anticholinergic effects and can be used to inhibit Parkinson's disease. | |||||||||||||||||||||
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Alimemazine | Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties. | |||||||||||||||||||||
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Promethazine hydrochloride | 99.85% | Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors. |
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Promazine hydrochloride | 99.53% | Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission. | ||||||||||||||||||||
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Promazine | 99.71% | Promazine (Romtiazin) is an antipsychotic and a dopamine receptor D2 antagonist. Promazine inhibits dopaminergic neurotransmission. | ||||||||||||||||||||
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(R)-Promethazine | (R)-Promethazine is the R-enantiomer of Promethazine (HY-B1296). Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects. | |||||||||||||||||||||
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Thiazinamium chloride | Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes. | |||||||||||||||||||||
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Isopromethazine hydrochloride | Isopromethazine hydrochloride is an impurity in the pharmaceutical preparations of Promethazine (HY-B1296). Promethazine is an N-substituted phenothiazine with the actions and the uses of the antihistamines (H1-receptor antagonists). | |||||||||||||||||||||
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rac N-Demethyl promethazine hydrochloride | N-demethyl Promethazine hydrochloride is a metabolite of Phenothiazine (HY-Y0055). Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. | |||||||||||||||||||||
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References
- [1]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. [Content Brief]
- [2]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [Content Brief]
- [3]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. [Content Brief]
- [4]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [Content Brief]
