619-14-7
Chemical Structure
3-Hydroxy-4-nitrobenzoic acid
- CAS No.: 619-14-7
- Formula:C7H5NO5
- Molecular Weight:183.12
IUPAC Name: 3-hydroxy-4-nitrobenzoic acid
InChIKey: XLDLRRGZWIEEHT-UHFFFAOYSA-N
SMILES: OC(C1=CC=C([N+]([O-])=O)C(O)=C1)=O
Biological Activity: 3-Hydroxy-4-nitrobenzoic acid is a substituted nitrobenzoic acid and synthetic intermediate. 3-Hydroxy-4-nitrobenzoic acid can serve as a starting material for acyloxy nitrobenzoic acid phospholipase A2 substrates, and also as a precursor and hydrolysis product of phospholipase A2 substrate esters, can provide a spectrophotometric signal in the form of nitrophenolate for monitoring phospholipase A2-catalyzed hydrolysis, and can be used in the preparation of BAPTA derivative chelators[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Hydroxy-4-nitrobenzoic acid | 99.71% | 3-Hydroxy-4-nitrobenzoic acid is a substituted nitrobenzoic acid and synthetic intermediate. 3-Hydroxy-4-nitrobenzoic acid can serve as a starting material for acyloxy nitrobenzoic acid phospholipase A2 substrates, and also as a precursor and hydrolysis product of phospholipase A2 substrate esters, can provide a spectrophotometric signal in the form of nitrophenolate for monitoring phospholipase A2-catalyzed hydrolysis, and can be used in the preparation of BAPTA derivative chelators. | ||||||||||||||||||||
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References
- [1]. Cho W, et al. A new class of phospholipase A2 substrates: kinetics of the phospholipase A2 catalyzed hydrolysis of 3-(acyloxy)-4-nitrobenzoic acids. Journal of the American Chemical Society. 1988 Jul;110(15):5166-71.
- [2]. Katayama S, et al. Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor. Journal of medicinal chemistry. 2003 Feb 27;46(5):691-701.
- [3]. Adams SR, et al. Biologically useful chelators that take up calcium (2+) upon illumination. Journal of the American Chemical Society. 1989 Sep;111(20):7957-68.
- [4]. Gillespie RJ, et al. Antagonists of the human A2A adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo [4, 5-d] pyrimidines. Journal of medicinal chemistry. 2009 Jan 8;52(1):33-47.
