63088-04-0
63088-04-0
Chemical Structure
(±)-threo-3-Methylglutamic acid
- CAS No.: 63088-04-0
- Formula:C6H11NO4
- Molecular Weight:161.16
IUPAC Name: 4-aminohex-5-enoic acid
InChIKey: FHJNAFIJPFGZRI-WUJLRWPWSA-N
SMILES: OC([C@@H](N)[C@H](C)CC(O)=O)=O
Biological Activity: (±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments[1][2].
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(±)-threo-3-Methylglutamic acid | (±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments. | |||||||||||||||||||||
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References
- [1]. Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7. [Content Brief]
- [2]. Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51. [Content Brief]
