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Cat. No.: HY-101227

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(±)-threo-3-Methylglutamic acid

(±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments.

For research use only. We do not sell to patients.

CAS No.: 63088-04-0
Formula: C₆H₁₁NO₄
Molecular Weight:161.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(±)-threo-3-Methylglutamic acid Chemical Structure

CAS No.: 63088-04-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

EAAT2

EAAT4

All EAAT Isoforms :

In Vitro

(±)-threo-3-Methylglutamic acid (0-300 µM) inhibits glutamate uptake by rod outer segments in a concentration-dependent manner with an IC₅₀ value of 38.35 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 63088-04-0
Molecular Weight 161.16
Formula C₆H₁₁NO₄
SMILES

OC([C@@H](N)[C@H](C)CC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7. [Content Brief]

[2]. Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(±)-threo-3-Methylglutamic acid

Congo Red

Dihydrokainic acid

DL-TBOA

TFB-TBOA

L-threo-3-Hydroxyaspartic acid

Evans Blue

Acid Red 94 sodium

cis-α-(Carboxycyclopropyl)glycine

Acid Red 94 sodium (Standard)

Congo Red (Standard)

UCPH-101

trans-4-Carboxy-L-proline

All EAAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

(±)-threo-3-Methylglutamic acid

Congo Red

Dihydrokainic acid

DL-TBOA

TFB-TBOA

L-threo-3-Hydroxyaspartic acid

Evans Blue

Acid Red 94 sodium

cis-α-(Carboxycyclopropyl)glycine

Acid Red 94 sodium (Standard)

Congo Red (Standard)

UCPH-101

trans-4-Carboxy-L-proline

All EAAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(±)-threo-3-Methylglutamic acid Related Classifications

HY-101227 Related Classifications

Bioz