717863-53-1
Chemical Structure
NRPa-308
- CAS No.: 717863-53-1
- Formula:C23H24N2O4S
- Molecular Weight:424.51
InChIKey: JCTQAQMMIBJHIS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C)C(S(=O)(NC2=CC=C(C)C=C2)=O)=C1)NC3=C(OCC)C=CC=C3
Biological Activity: NRPa-308 is a potent and orally active Neuropilin-1 (NRP-1) antagonist with an IC50 of 42 μM for inhibiting VEGF-A165 binding to NRP-1. NRPa-308 blocks the specific interaction between VEGF-A165 and NRP-1. NRPa-308 effectively suppresses angiogenesis in vitro and in vivo and reduces the viability of a broad spectrum of human solid and haematological cancer cells. NRPa-308 inhibits tumor growth and prolongs median survival in a human breast cancer xenograft mouse model. NRPa-308 can be used for the research of multiple human malignancies including solid tumors and hematological cancers[1].
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NRPa-308 | 98.96% | NRPa-308 is a potent and orally active Neuropilin-1 (NRP-1) antagonist with an IC50 of 42 μM for inhibiting VEGF-A165 binding to NRP-1. NRPa-308 blocks the specific interaction between VEGF-A165 and NRP-1. NRPa-308 effectively suppresses angiogenesis in vitro and in vivo and reduces the viability of a broad spectrum of human solid and haematological cancer cells. NRPa-308 inhibits tumor growth and prolongs median survival in a human breast cancer xenograft mouse model. NRPa-308 can be used for the research of multiple human malignancies including solid tumors and hematological cancers. | ||||||||||||||||||||
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