848217-46-9
Chemical Structure
MLS8091
- CAS No.: 848217-46-9
- Formula:C21H16N4O2S2
- Molecular Weight:420.51
InChIKey: ASVVJSABVKPZKA-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CS1)(C2=C(N)N(CC3=CC=CC=C3)C4=C2N=C5C=CC=CC5=N4)=O
Biological Activity: MLS8091 is a highly selective inhibitor of the human cytomegalovirus (HCMV) helicase-primase complex with antiviral activity. MLS8091 inhibits HCMV replication during the early and late stages of the virus, and suppresses viral DNA replication as well as all HCMV viral proteins. MLS8091 inhibits guinea pig cytomegalovirus replication, and exerts an additive effect when combined with Letermovir (HY-15233). MLS8091 can be used in studies related to human cytomegalovirus infection[1][2].
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MLS8091 | MLS8091 is a highly selective inhibitor of the human cytomegalovirus (HCMV) helicase-primase complex with antiviral activity. MLS8091 inhibits HCMV replication during the early and late stages of the virus, and suppresses viral DNA replication as well as all HCMV viral proteins. MLS8091 inhibits guinea pig cytomegalovirus replication, and exerts an additive effect when combined with Letermovir (HY-15233). MLS8091 can be used in studies related to human cytomegalovirus infection. | |||||||||||||||||||||
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- [1]. Kapoor A, et al. Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. Journal of medicinal chemistry. 2020 Apr 23;63(8):3896-3907. [Content Brief]
- [2]. Kapoor A, et al. A novel inhibitor of human cytomegalovirus acts through a specific antiviral mechanism that involves the helicase-primase complex. Antimicrobial agents and chemotherapy. 2026 Jul 13. [Content Brief]
Keywords
