852612-00-1
852612-00-1
Chemical Structure
JNJ-16567083
Synonym(s): EMQMCM free base
- CAS No.: 852612-00-1
- Formula:C20H25NO2
- Molecular Weight:311.42
IUPAC Name: (3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexyl)methanone
InChIKey: VEURHZYLLRSEGL-UHFFFAOYSA-N
SMILES: O=C(C1CCC(CC1)OC)C2=CC3=C(N=C(C)C(CC)=C3)C=C2
Biological Activity: JNJ-16567083 (EMQMCM free base) is a selective, non-competitive metabotropic glutamate receptor 1 (mGluR1) antagonist with a Ki value of 0.87 nM. JNJ-16567083 can be radiolabeled to serve as a PET radiotracer. JNJ-16567083 can be used for research on Parkinson's disease and asthma[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JNJ-16567083 | JNJ-16567083 (EMQMCM free base) is a selective, non-competitive metabotropic glutamate receptor 1 (mGluR1) antagonist with a Ki value of 0.87 nM. JNJ-16567083 can be radiolabeled to serve as a PET radiotracer. JNJ-16567083 can be used for research on Parkinson's disease and asthma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Huang Y, et al. A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone. Journal of medicinal chemistry. 2005 Aug 11;48(16):5096-9.
- [2]. Sobrio F, et al. Radiosynthesis of carbon-11 and fluorine-18 labelled radiotracers to image the ionotropic and metabotropic glutamate receptors. Journal of labelled compounds & radiopharmaceuticals. 2013;56(3-4):180-6.
- [3]. Fuchigami T, et al. Development of PET and SPECT probes for glutamate receptors. TheScientificWorldJournal. 2015;2015:716514.
- [4]. Rodriguez P, et al. A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide. Journal of medicinal chemistry. 2025 Sep 25;68(18):19107-19121. [Content Brief]
