901117-03-1
Chemical Structure
BIO-11006
- CAS No.: 901117-03-1
- Formula:C46H75N13O15
- Molecular Weight:1050.17
IUPAC Name: acetylglycyl-L-alanyl-L-glutaminyl-L-phenylalanyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-alanyl-L-lysine
InChIKey: KCSNGWMKFYVMKF-HGYIIGRXSA-N
SMILES: CC(NCC(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O
Biological Activity: BIO-11006 is a peptide that inhibits the function of the MARCKS protein. BIO-11006 attenuates LPS-induced neutrophil influx into the lungs, NF-κB activation, and expression of the proinflammatory cytokines KC and TNF-α. BIO-11006 also reverses disease progression in an LPS-induced mouse lung injury model. BIO-11006 is indicated for research on acute lung injury/acute respiratory distress syndrome (ALI/ARDS)[1].
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BIO-11006 | BIO-11006 is a peptide that inhibits the function of the MARCKS protein. BIO-11006 attenuates LPS-induced neutrophil influx into the lungs, NF-κB activation, and expression of the proinflammatory cytokines KC and TNF-α. BIO-11006 also reverses disease progression in an LPS-induced mouse lung injury model. BIO-11006 is indicated for research on acute lung injury/acute respiratory distress syndrome (ALI/ARDS). | |||||||||||||||||||||
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