920915-26-0
Chemical Structure
ZNU-IMB-Z15
- CAS No.: 920915-26-0
- Formula:C20H17N3O3S2
- Molecular Weight:411.50
InChIKey: ZBSYDTSUARCOGR-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(C2=CC=CS2)=CS1)C3=CC=C(OCC4=C(C)ON=C4C)C=C3
Biological Activity: ZNU-IMB-Z15 is a bifunctional, selective androgen receptor (AR) antagonist and degrader. ZNU-IMB-Z15 directly binds to the ligand-binding domain (LBD) and transactivation function 1 (AF1) of AR, with an IC50 of 63.3 nM for competitive binding to AR LBD and a KD of 0.93 μM for AR AF1. ZNU-IMB-Z15 inhibits AR transcriptional activity and promotes the degradation of AR and ARV7 via the ubiquitin-proteasome pathway. ZNU-IMB-Z15 can be used for the research of castration-resistant prostate cancer[1].
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ZNU-IMB-Z15 | 99.03% | ZNU-IMB-Z15 is a bifunctional, selective androgen receptor (AR) antagonist and degrader. ZNU-IMB-Z15 directly binds to the ligand-binding domain (LBD) and transactivation function 1 (AF1) of AR, with an IC50 of 63.3 nM for competitive binding to AR LBD and a KD of 0.93 μM for AR AF1. ZNU-IMB-Z15 inhibits AR transcriptional activity and promotes the degradation of AR and ARV7 via the ubiquitin-proteasome pathway. ZNU-IMB-Z15 can be used for the research of castration-resistant prostate cancer. | ||||||||||||||||||||
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