954389-09-4
Chemical Structure
JTK-853
- CAS No.: 954389-09-4
- Formula:C28H23F7N6O4S2
- Molecular Weight:704.64
IUPAC Name: (R)-4-(5-cyclopropylthiazolo[4,5-d]pyrimidin-2-yl)-N-(3-fluoro-4-(trifluoromethoxy)benzyl)-1-((4-(trifluoromethyl)phenyl)sulfonyl)piperazine-2-carboxamide
InChIKey: JQLOVYLALGSISI-HXUWFJFHSA-N
SMILES: O=C([C@@H]1N(S(=O)(C2=CC=C(C(F)(F)F)C=C2)=O)CCN(C3=NC4=NC(C5CC5)=NC=C4S3)C1)NCC6=CC=C(OC(F)(F)F)C(F)=C6
Biological Activity: JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively.
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JTK-853 | JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively. | |||||||||||||||||||||
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Keywords
