97451-46-2
Chemical Structure
Glutathione monoisopropyl ester
Synonym(s): Glutathione isopropyl ester; YM 737
- CAS No.: 97451-46-2
- Formula:C13H23N3O6S
- Molecular Weight:349.40
IUPAC Name: N5-((R)-1-((2-isopropoxy-2-oxoethyl)amino)-3-mercapto-1-oxopropan-2-yl)-L-glutamine
InChIKey: MVNCPACIPXNJIW-IUCAKERBSA-N
SMILES: CC(C)OC(CNC([C@H](CS)NC(CC[C@H](N)C(O)=O)=O)=O)=O
Biological Activity: Glutathione monoisopropyl ester (Glutathione isopropyl ester) is an ester derivative of glutathione. Glutathione monoisopropyl ester can increase glutathione concentrations in tissues such as the liver, lungs, heart, and brain of mice, exerting a dose-dependent protective effect against liver injury. Glutathione monoisopropyl ester effectively inhibits ultraviolet-induced lipid peroxidation, inflammatory responses, and tumorigenesis in the skin of hairless mice by maintaining epidermal glutathione levels. Glutathione monoisopropyl ester also inhibits the progression of X-ray-induced cataracts in rats[1][2][3].
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Glutathione monoisopropyl ester | Glutathione monoisopropyl ester (Glutathione isopropyl ester) is an ester derivative of glutathione. Glutathione monoisopropyl ester can increase glutathione concentrations in tissues such as the liver, lungs, heart, and brain of mice, exerting a dose-dependent protective effect against liver injury. Glutathione monoisopropyl ester effectively inhibits ultraviolet-induced lipid peroxidation, inflammatory responses, and tumorigenesis in the skin of hairless mice by maintaining epidermal glutathione levels. Glutathione monoisopropyl ester also inhibits the progression of X-ray-induced cataracts in rats. | |||||||||||||||||||||
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- [1]. Uhlig S, et al. Glutathione enhancement in various mouse organs and protection by glutathione isopropyl ester against liver injury. Biochem Pharmacol. 1990 Jun 15;39(12):1877-81. [Content Brief]
- [2]. Kobayashi S, et al. Glutathione isopropyl ester reduces UVB-induced skin damage in hairless mice. Photochem Photobiol. 1996 Jan;63(1):106-10. [Content Brief]
- [3]. Kobayashi S, et al. Glutathione isopropyl ester (YM737) inhibits the progression of X-ray-induced cataract in rats. Curr Eye Res. 1993 Feb;12(2):115-22. [Content Brief]
Keywords
