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Art. -Nr.: HY-147253A

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Brogidirsen sodium

(Synonyms: NS 089 sodium; NCNP 02 sodium)

Brogidirsen (NS 089; NCNP 02) sodium is a a dual-targeting antisense oligonucleotide. Brogidirsen sodium can induce dystrophin protein experession. Brogidirsen sodium can be used for the research of Duchenne muscular dystrophy.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₈₀H₄₁₆N₁₁₉Na₂₄O₁₀₅P₂₃
Molecular Weight:7865.72 (free acid)

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Brogidirsen sodium Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- In Vitro
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Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Brogidirsen (1-10 μM; 72 h) sodium induces dose-dependent exon 44 skipping and dystrophin protein expression in donor-derived MYOD1-UDCs, myotubes, and MYOD1-transduced fibroblasts from DMD patients amenable to exon 44 skipping^[2].
Brogidirsen (1-10 μM) sodium exhibits an EC₅₀ of 7.12 μM for exon 44 skipping in healthy donor-derived MYOD1-UDCs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 7865.72 (free acid)
Formel C₂₈₀H₄₁₆N₁₁₉Na₂₄O₁₀₅P₂₃
SMILES

[Brogidirsen (sodium)]
Synonyms

NS 089 sodium; NCNP 02 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

Verweise

[1]. Aoki Y, et al. Brogidirsen-The First Dual-Targeting Exon 44 Skipping Drug for Duchenne Muscular Dystrophy: Safety, Tolerability, and High Dystrophin Restoration in Long-Term Clinical Studies[C]//MOLECULAR THERAPY. 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA: CELL PRESS, 2025, 33(4).

[2]. Komaki H, et al. Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy. Cell Rep Med. 2025;6(1):101901. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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- In Vitro
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Brogidirsen sodium

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Calculators

Help & FAQs

Brogidirsen sodium Related Classifications

HY-147253A Related Classifications