331-38-4
Chemical Structure
L-Balenine
- CAS. Nr.: 331-38-4
- Formula:C10H16N4O3
- Molecular Weight:240.26
InChIKey: SLRNWACWRVGMKD-QMMMGPOBSA-N
SMILES: NCCC(N[C@H](C(O)=O)CC1=CN(C)C=N1)=O
Biological Activity: L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms[1][2][3].
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L-Balenine | L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms. | |||||||||||||||||||||
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References
- [1]. Yang M, et al. Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells. Mar Drugs. 2022;20(5):313. Published 2022 May 5. [Content Brief]
- [2]. Takahashi K, et al. L-balenine inhibits the catalytic activity of Pin1, a peptidyl prolyl cis/trans-isomerase[J]. Personalized Medicine Universe, 2020, 9: 51-58.
- [3]. Dolan E, et al. Skeletal muscle histidine-containing dipeptide contents are increased in freshwater turtles (C. picta bellii) with cold-acclimation[J]. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2021, 262: 111071.
