TSPAN5 - tetraspanin 5 Gene

Also Known as NET4; NET-4; TM4SF9; TSPAN-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10098

About TSPAN5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,470,367-98,658,611 (from NCBI)

This gene has 10 transcripts (splice variants), 156 orthologues and 32 paralogues. Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN5 Products (1)

mRNA Protein Name
NM_005723.4 NP_005714.2 tetraspanin-5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23091066 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23091066 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23091066 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23091066 GOA
involved in protein maturation IMP
IMP: Inferred from mutant phenotype
23091066 GOA
involved in regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
28600292 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IDA
IDA: Inferred from direct assay
23091066 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN5 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (14 - 258)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

tetraspanin-5

  • tetraspan NET-4

TSPAN5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TSPAN5 P62079 ADAM10 Homo sapiens O14672
Anti Bait CoIP
26686862
Intra
TSPAN5 P62079 ADAM10 Homo sapiens O14672
Anti Tag CoIP
26686862
Intra
TSPAN5 P62079 ADAM10 Homo sapiens O14672
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15171 TSPAN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TSPAN5 RGD RGD:1303176
Bos taurus TSPAN5 VGNC VGNC:36440
Macaca mulatta TSPAN5 VGNC VGNC:79086
Felis catus TSPAN5 VGNC VGNC:66635
Canis familiaris TSPAN5 VGNC VGNC:47923
Mus musculus TSPAN5 MGD MGI:1928096
Others TSPAN5 NCBI