Fig4 - FIG4 phosphoinositide 5-phosphatase Gene

Also Known as Sac3; A530089I17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 103199

Summary

Predicted to enable phosphatidylinositol bisphosphate Phosphatase activity; phosphatidylinositol-3-phosphatase activity; and phosphatidylinositol-4-phosphate Phosphatase activity. Acts upstream of or within several processes, including negative regulation of myelination; nervous system development; and phosphatidylinositol metabolic process. Predicted to be located in endosome membrane and lipid droplet. Predicted to colocalize with Golgi apparatus; endoplasmic reticulum; and recycling endosome. Is expressed in cerebral cortex; ganglia; nucleus pulposus; thymus primordium; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4J and Yunis-Varon syndrome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Fig4 Products (1)

mRNA Protein Name
NM_133999.1 NP_598760.1 polyphosphoinositide phosphatase

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
17572665 MGI
acts upstream of or within myelin assembly IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of myelination IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of myelination IMP
IMP: Inferred from mutant phenotype
22028665 MGI
acts upstream of or within negative regulation of myelination IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within negative regulation of myelination IMP
IMP: Inferred from mutant phenotype
22028665 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
17572665 MGI
acts upstream of or within phosphatidylinositol metabolic process IMP
IMP: Inferred from mutant phenotype
17572665 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
17572665 MGI
acts upstream of or within vacuole organization IMP
IMP: Inferred from mutant phenotype
17572665 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyphosphoinositide phosphatase

  • FIG4 homolog

  • SAC domain-containing protein 3

  • Sac domain-containing inositol phosphatase 3

  • phosphatidylinositol 3,5-bisphosphate 5-phosphatase

  • serine-protein phosphatase FIG4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04944 FIG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22170 Fig4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fig4 NCBI NCBI:9896