ARL8A - ADP ribosylation factor like GTPase 8A Gene

Also Known as GIE2; ARL10B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 127829

About ARL8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,133,404-202,144,737 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues.

Summary

Enables GTP binding activity. Predicted to be involved in chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]

ARL8A Products (2)

mRNA Protein Name
NM_001256129.2 NP_001243058.1 ADP-ribosylation factor-like protein 8A isoform 2
NM_138795.4 NP_620150.1 ADP-ribosylation factor-like protein 8A isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTP binding IDA
IDA: Inferred from direct assay
15331635 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24955142 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15331635 GOA
located in midbody IDA
IDA: Inferred from direct assay
15331635 GOA
located in spindle midzone IDA
IDA: Inferred from direct assay
15331635 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL8A Protein Structure

Arf

Arf: ADP-ribosylation factor family (12 - 179)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 8A

  • ADP-ribosylation factor-like 10B

ARL8A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ARL8A Q96BM9 PUF60 Homo sapiens Q9UHX1
Y2H Array
25416956
Intra
ARL8A Q96BM9 PUF60 Homo sapiens Q9UHX1
Validated Y2H
25416956
Intra
ARL8A Q96BM9 MOCOS Homo sapiens Q96EN8
Anti Tag CoIP
33961781
Intra
ARL8A Q96BM9 MOCOS Homo sapiens Q96EN8
Validated Y2H
32296183
Intra
ARL8A Q96BM9 UQCRH Homo sapiens P07919
Y2H Prey Pooling
25416956
Intra
ARL8A Q96BM9 PLEKHM1 Homo sapiens Q9Y4G2
Anti Tag CoIP
28325809
Intra
ARL8A Q96BM9 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
33961781
Intra
ARL8A Q96BM9 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross
ARL8A Q96BM9 Q86500-PRO_0000041224 Rubella virus Q86500-PRO_0000041224
Protein Array
24955142
Cross
ARL8A Q96BM9 Q86500-PRO_0000041224 Rubella virus Q86500-PRO_0000041224
Pull Down
24955142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Non-Proliferative Fibrocystic Change Of The Breast

  • Non-Proliferative Fibrocystic Change

  • Breast Fibrocystic Change, Non-Proliferative Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00998 ARL8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARL8A RGD RGD:1565940
Felis catus ARL8A VGNC VGNC:59929
Macaca mulatta ARL8A VGNC VGNC:69900
Bos taurus ARL8A VGNC VGNC:26153
Mus musculus ARL8A MGD MGI:1915974
Others ARL8A NCBI