Creb1 - cAMP responsive element binding protein 1 Gene

Also Known as Creb; Creb-1; 2310001E10Rik; 3526402H21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12912

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of biosynthetic process; and protein stabilization. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and cellular response to Leukemia Inhibitory Factor. Located in chromatin and nucleus. Part of ATF4-CREB1 transcription factor complex. Is expressed in several structures, including genitourinary system; limb; maxillary process; peripheral nervous system ganglion; and telencephalon. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Creb1 Products (3)

mRNA Protein Name
NM_001037726.1 NP_001032815.1 cyclic AMP-responsive element-binding protein 1 isoform C
NM_009952.2 NP_034082.1 cyclic AMP-responsive element-binding protein 1 isoform B
NM_133828.2 NP_598589.2 cyclic AMP-responsive element-binding protein 1 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
11354513 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20876357 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12220541 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28763438 MGI
enables cAMP response element binding IDA
IDA: Inferred from direct assay
23729669 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17550780 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15030764 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
11988169 MGI
involved in cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
16427017 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in cellular response to retinoic acid IMP
IMP: Inferred from mutant phenotype
20876357 MGI
acts upstream of or within cellular response to zinc ion IDA
IDA: Inferred from direct assay
23716681 MGI
involved in circadian rhythm IDA
IDA: Inferred from direct assay
20852621 MGI
acts upstream of hormone secretion IMP
IMP: Inferred from mutant phenotype
16141355 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
16141355 MGI
acts upstream of or within lung epithelium development IMP
IMP: Inferred from mutant phenotype
21408140 MGI
acts upstream of or within lung saccule development IMP
IMP: Inferred from mutant phenotype
21408140 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
16141355 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
23223304 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
30566056 MGI
acts upstream of osteoclast differentiation IDA
IDA: Inferred from direct assay
23395171 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
16141355 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
21728997 MGI
acts upstream of or within positive regulation of cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
24364879 MGI
involved in positive regulation of fat cell differentiation IGI
IGI: Inferred from genetic interaction
21728997 MGI
acts upstream of or within positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
16141355 MGI
involved in positive regulation of lipid biosynthetic process IGI
IGI: Inferred from genetic interaction
21728997 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16141355 MGI
acts upstream of or within positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
23395171 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18252718 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20852621 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20876357 MGI
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
21728997 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12220541 MGI
acts upstream of or within regulation of cell size IGI
IGI: Inferred from genetic interaction
12015964 MGI
involved in regulation of testosterone biosynthetic process IDA
IDA: Inferred from direct assay
21333348 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12871976 MGI
involved in response to glucagon IMP
IMP: Inferred from mutant phenotype
20852621 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9098922 MGI
acts upstream of or within secretory granule organization IMP
IMP: Inferred from mutant phenotype
21408140 MGI
acts upstream of or within type I pneumocyte differentiation IMP
IMP: Inferred from mutant phenotype
21408140 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of ATF4-CREB1 transcription factor complex IDA
IDA: Inferred from direct assay
12871976 MGI
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
12871976 MGI
located in chromatin IDA
IDA: Inferred from direct assay
16427017 MGI
located in chromatin IMP
IMP: Inferred from mutant phenotype
20876357 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
21728997 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7565774 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
11354513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03148 CREB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P4497 Prolylserine / Unkown
HY-RS18270 Creb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24748 Creb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Creb1 NCBI NCBI:1385