Rspo1 - R-spondin 1 Gene

Also Known as Rspondin; R-spondin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192199

Summary

Enables heparin binding activity and signaling receptor binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Apr 2022]

Rspo1 Products (1)

mRNA Protein Name
NM_138683.2 NP_619624.2 R-spondin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables heparin binding IDA
IDA: Inferred from direct assay
16543246 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21693646 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
16543246 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
21991325 MGI
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
21693646 MGI
acts upstream of or within positive regulation of non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21991325 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21991325 MGI
acts upstream of or within regulation of male germ cell proliferation IMP
IMP: Inferred from mutant phenotype
21991325 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
14732490 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14732490 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

R-spondin-1

  • R-spondin homolog

  • cristin-3

  • cysteine-rich and single thrombospondin domain-containing protein 3

  • mCristin-3

  • roof plate-specific spondin-1

  • thrombospondin type 1 domain containing gene Rspondin

Recombinant Rspo1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76012 RSPO1/R-spondin-1 Protein, Mouse (CHO, His) Q9Z132/NP_619624.2 (S21-Q265) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78344 RSPO1/R-spondin-1 Protein, Mouse (HEK293, His) Q9Z132 (S21-Q265) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700255 RSPO1/R-spondin-1 Protein, Mouse (189a.a, His) Q9Z132 (S21-G209) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P10810 QPH-FR Inhibitor 99.54% Unkown
HY-RS12305 RSPO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16692 Rspo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23127 Rspo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990501 Anti-RSPO1 Antibody Inhibitor 96.18% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rspo1 NCBI NCBI:284654