Mttp - microsomal triglyceride transfer protein Gene

Also Known as MTP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310900

About Mttp

Primary_assembly 2: 226,613,090-226,654,239 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 210 orthologues and is associated with 11 phenotypes.

Summary

Enables Apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including Cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and rough endoplasmic reticulum. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Mttp Products (1)

mRNA Protein Name
NM_001107727.1 NP_001101197.1 microsomal triglyceride transfer protein large subunit precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables apolipoprotein binding IPI
IPI: Inferred from physical interaction
11830580 RGD
enables cholesterol transfer activity IDA
IDA: Inferred from direct assay
15897609 RGD
enables lipid transporter activity IDA
IDA: Inferred from direct assay
15383310 RGD
enables phosphatidylcholine transfer activity IMP
IMP: Inferred from mutant phenotype
16478722 RGD
enables phosphatidylethanolamine transfer activity IDA
IDA: Inferred from direct assay
15897609 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11830580 RGD
enables triglyceride transfer activity IDA
IDA: Inferred from direct assay
15897609 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cholesterol homeostasis IEP
IEP: Inferred from expression pattern
14972350 RGD
involved in lipid transport IDA
IDA: Inferred from direct assay
15383310 RGD
involved in lipoprotein metabolic process IDA
IDA: Inferred from direct assay
11830580 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
16651714 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11830580 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
15383310 RGD
located in microvillus membrane IDA
IDA: Inferred from direct assay
15383310 RGD
located in vesicle IDA
IDA: Inferred from direct assay
15383310 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microsomal triglyceride transfer protein large subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-50670 DGAT-1 inhibitor 2 95.33% Unkown
HY-RS08822 MTTP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08823 Mttp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08824 Mttp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mttp NCBI NCBI:4547